The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materials

DSpace Repository

The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materials

Details

Files for download

Find Full text There are no files associated with this item..

Overview of item record
Publication Article, peer reviewed scientific
Title The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materials
Author Tovar, Nick ; Jimbo, Ryo ; Witek, Lukasz ; Anchieta, Rodolfo ; Yoo, Daniel ; Manne, Lakshmipradha ; Machado, Lucas ; Gangolli, Riddhi ; Coelho, Paulo G.
Date 2014
English abstract
In this study, the physicochemical characteristics of calcium phosphate based bioactive ceramics of different compositions and blends presenting similar micro/nanoporosity and micrometer scale surface texture were characterized and evaluated in an in vivo model. Prior to the animal experiment, the porosity, surface area, particle size distribution, phase quantification, and dissolution of the materials tested were evaluated. The bone regenerative properties of the materials were evaluated using a rabbit calvaria model. After 2, 4, and 8 weeks, the animals were sacrificed and all samples were subjected to histologic observation and histomorphometric analysis. The material characterization showed that all materials tested presented variation in particle size, porosity and composition with different degrees of HA/TCP/lower stoichiometry phase ratios. Histologically, the calvarial defects presented temporal bone filling suggesting that all material groups were biocompatible and osteoconductive. Among the different materials tested, there were significant differences found in the amount of bone formation as a function of time. At 8 weeks, the micro/nanoporous material presenting similar to 55,TCP:45%,HA composition ratio presented higher amounts of new bone regeneration relative to other blends and a decrease in the amount of soft tissue infiltration. (C) 2014 Elsevier B.V. All rights reserved.
DOI https://doi.org/10.1016/j.msec.2014.07.048 (link to publisher's fulltext.)
Publisher Elsevier
Host/Issue Materials Science and Engineering C;
Volume 43
ISSN 0928-4931
Language eng (iso)
Subject Calcium phosphate materials
Porosity
Animal experiment
Histomorphometry
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/27434 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA.
Facebook

This item appears in the following Collection(s)

Details

Search


Browse

My Account

Statistics