The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materials

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The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materials

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dc.contributor.author Tovar, Nick en_US
dc.contributor.author Jimbo, Ryo en_US
dc.contributor.author Witek, Lukasz en_US
dc.contributor.author Anchieta, Rodolfo en_US
dc.contributor.author Yoo, Daniel en_US
dc.contributor.author Manne, Lakshmipradha en_US
dc.contributor.author Machado, Lucas en_US
dc.contributor.author Gangolli, Riddhi en_US
dc.contributor.author Coelho, Paulo G. en_US
dc.date.accessioned 2019-01-16T13:15:48Z
dc.date.available 2019-01-16T13:15:48Z
dc.date.issued 2014 en_US
dc.identifier.issn 0928-4931 en_US
dc.identifier.uri http://hdl.handle.net/2043/27434
dc.description.abstract In this study, the physicochemical characteristics of calcium phosphate based bioactive ceramics of different compositions and blends presenting similar micro/nanoporosity and micrometer scale surface texture were characterized and evaluated in an in vivo model. Prior to the animal experiment, the porosity, surface area, particle size distribution, phase quantification, and dissolution of the materials tested were evaluated. The bone regenerative properties of the materials were evaluated using a rabbit calvaria model. After 2, 4, and 8 weeks, the animals were sacrificed and all samples were subjected to histologic observation and histomorphometric analysis. The material characterization showed that all materials tested presented variation in particle size, porosity and composition with different degrees of HA/TCP/lower stoichiometry phase ratios. Histologically, the calvarial defects presented temporal bone filling suggesting that all material groups were biocompatible and osteoconductive. Among the different materials tested, there were significant differences found in the amount of bone formation as a function of time. At 8 weeks, the micro/nanoporous material presenting similar to 55,TCP:45%,HA composition ratio presented higher amounts of new bone regeneration relative to other blends and a decrease in the amount of soft tissue infiltration. (C) 2014 Elsevier B.V. All rights reserved. en_US
dc.format.extent 9
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.subject Calcium phosphate materials en_US
dc.subject Porosity en_US
dc.subject Animal experiment en_US
dc.subject Histomorphometry en_US
dc.subject.classification Medicine en_US
dc.title The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materials en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Odontology
dc.identifier.doi 10.1016/j.msec.2014.07.048 en_US
dc.subject.srsc Research Subject Categories::MEDICINE en_US
dc.relation.ispartofpublication Materials Science and Engineering C;
dc.relation.ispartofpublicationvolume 43 en_US
dc.description.authorversion No en_US
dc.identifier.isiid 000342529000058
dc.identifier.pmid 25175238
dc.format.ePage 480
dc.format.sPage 472
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