Inflammation and cholesterol

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Inflammation and cholesterol

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dc.contributor.author Nilsson, J
dc.contributor.author Ares, Mikko PS
dc.contributor.author Lindholm, Maud
dc.contributor.author Nordin Fredrikson, Gunilla
dc.contributor.author Jovinge, S
dc.date.accessioned 2006-07-27T09:01:02Z
dc.date.available 2006-07-27T09:01:02Z
dc.date.issued 2002
dc.identifier.citation Suppl A, A18-A25 en
dc.identifier.issn 1520-765X
dc.identifier.uri http://hdl.handle.net/2043/2782
dc.description.abstract Atherosclerosis develops as a result of a chronic arterial inflammation and intimal fibrosis. The disease represents in many respects a vascular repair process activated in response to injury caused by toxic breakdown products of aggregated and oxidized lipoproteins. The initial response of the artery involves expression of adhesion molecules and recruitment of leukocytes. Degenerated lipoproteins are removed from the extracellular space by macrophages. If lipoproteins continue to accumulate, the inflammatory process becomes chronic and cytokines stimulate smooth muscle to migrate into the intima. These cells proliferate and form an atherosclerotic plaque. Plaque cell death and inflammation in response to oxidized lipids and other toxic factors may cause plaques to rupture. en
dc.language.iso eng en
dc.publisher Oxford University Press en
dc.subject.classification Medicine en
dc.title Inflammation and cholesterol en
dc.type Article, peer reviewed scientific en
dc.contributor.department Malmö University. Faculty of Health and Society en
dc.identifier.doi 10.1161/01.ATV.0000067935.02679.B0
dc.relation.ispartofpublication European heart journal supplements : journal of the European Society of Cardiology en
dc.relation.ispartofpublicationvolume 4 en
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