Development of criteria for investigation of periapical tissue from root-filled teeth.

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Development of criteria for investigation of periapical tissue from root-filled teeth.

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Publication Article, peer reviewed scientific
Title Development of criteria for investigation of periapical tissue from root-filled teeth.
Author Danesh, Noushin ; Ljunggren, Anna Camilla ; Wolf, Eva ; Fransson, Helena
Date 2019
English abstract
Objective: To develop and assess a set of criteria to grade inflammation including relative area of inflammation in periapical lesions in endodontically treated teeth. Material and methods: A set of criteria was developed, encompassing data on: Lymphocytes, denoting chronic inflammation, were graded 0 (occasional) to 4 (heavy/dense inflammation). Polymorphonuclear cells, denoting acute inflammation, were graded 0 (none) to 2 (many). The third parameter, area of inflammation, that is, the relative area of the specimen that was inflamed, was graded 0 (none) to 4 (76–100%). The criteria were tested on 199 consecutive biopsies from 180 patients (aged 31–75 years). Information about symptoms was retrieved from the referrals. Mann–Whitney’s U-test was used to calculate possible differences in average values for the histopathological variables in the two groups of patients: symptomatic or asymptomatic. Results: Using the criteria, varying grades of inflammation were seen in the biopsies. The majority showed few or no PMN cells. There was a correlation between symptoms and the extent of infiltration of lymphocytes and plasma cells (p = .001), PMN cells (p < .001) and the area of inflammation (p = .002): biopsies from the asymptomatic patients exhibited less pronounced and relatively smaller areas of inflammation. Conclusions: Using the criteria on a specific selection of root-filled teeth with persisting apical periodontitis, periapical inflammation was common, but varied in extent and severity. The inflammation was less pronounced and affected a relatively smaller area in asymptomatic teeth, although outliers in both directions were identified.
DOI https://doi.org/10.1080/00016357.2018.1538534 (link to publisher's fulltext.)
Publisher Taylor & Francis
Host/Issue Acta odontologica Scandinavica;4
Volume 77
ISSN 1502-3850
Language eng (iso)
Subject Apical periodontitis
biopsy
lymphocytes
pathology
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/27889 Permalink to this page
Link to publication in DiVA Find this research publication in DiVA.
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