Development of criteria for investigation of periapical tissue from root-filled teeth.

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Development of criteria for investigation of periapical tissue from root-filled teeth.

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dc.contributor.author Danesh, Noushin en_US
dc.contributor.author Ljunggren, Anna Camilla en_US
dc.contributor.author Wolf, Eva en_US
dc.contributor.author Fransson, Helena en_US
dc.date.accessioned 2019-02-19T08:29:42Z
dc.date.available 2019-02-19T08:29:42Z
dc.date.issued 2019 en_US
dc.identifier.issn 1502-3850 en_US
dc.identifier.other 30623701
dc.identifier.uri http://hdl.handle.net/2043/27889
dc.description.abstract Objective: To develop and assess a set of criteria to grade inflammation including relative area of inflammation in periapical lesions in endodontically treated teeth. Material and methods: A set of criteria was developed, encompassing data on: Lymphocytes, denoting chronic inflammation, were graded 0 (occasional) to 4 (heavy/dense inflammation). Polymorphonuclear cells, denoting acute inflammation, were graded 0 (none) to 2 (many). The third parameter, area of inflammation, that is, the relative area of the specimen that was inflamed, was graded 0 (none) to 4 (76–100%). The criteria were tested on 199 consecutive biopsies from 180 patients (aged 31–75 years). Information about symptoms was retrieved from the referrals. Mann–Whitney’s U-test was used to calculate possible differences in average values for the histopathological variables in the two groups of patients: symptomatic or asymptomatic. Results: Using the criteria, varying grades of inflammation were seen in the biopsies. The majority showed few or no PMN cells. There was a correlation between symptoms and the extent of infiltration of lymphocytes and plasma cells (p = .001), PMN cells (p < .001) and the area of inflammation (p = .002): biopsies from the asymptomatic patients exhibited less pronounced and relatively smaller areas of inflammation. Conclusions: Using the criteria on a specific selection of root-filled teeth with persisting apical periodontitis, periapical inflammation was common, but varied in extent and severity. The inflammation was less pronounced and affected a relatively smaller area in asymptomatic teeth, although outliers in both directions were identified. en_US
dc.language.iso eng en_US
dc.publisher Taylor & Francis en_US
dc.subject Apical periodontitis en_US
dc.subject biopsy en_US
dc.subject lymphocytes en_US
dc.subject pathology en_US
dc.subject.classification Medicine en_US
dc.title Development of criteria for investigation of periapical tissue from root-filled teeth. en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Odontology en_US
dc.identifier.doi 10.1080/00016357.2018.1538534 en_US
dc.subject.srsc Research Subject Categories::ODONTOLOGY en_US
dc.relation.ispartofpublication Acta odontologica Scandinavica;4
dc.relation.ispartofpublicationvolume 77
dc.description.authorversion No en_US
dc.identifier.pmid 30623701
dc.format.ePage 274 en_US
dc.format.sPage 269 en_US
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