Effectiveness of Casein Phosphopeptide- Amorphous Calcium Phosphate (CPP-ACP) in Remineralization of Early Carious Lesions. A systematic review

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Effectiveness of Casein Phosphopeptide- Amorphous Calcium Phosphate (CPP-ACP) in Remineralization of Early Carious Lesions. A systematic review

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dc.contributor.author Albahoth, Ahmad
dc.date.accessioned 2020-10-12T13:00:07Z
dc.date.available 2020-10-12T13:00:07Z
dc.date.issued 2019 en_US
dc.identifier.uri http://hdl.handle.net/2043/32890
dc.description.abstract Abstract Aim To assess the effectiveness of CPP-ACP in combination with daily fluoride use versus daily fluoride use alone on remineralization of early carious lesions in randomized controlled trials (RCTs). Material and methods A systematic literature search was conducted following the PRISMA 2009 statement. The literature obtained from the searches in electronic databases were reviewed individually by two reviewers and the relevant titles and abstracts were selected with specific inclusion and exclusion criteria. The search was limited to articles published in English. Only randomized controlled clinical trials (RCTs) in which CPP-ACP was delivered by cream form were selected. The included studies were assessed for risk of bias and quality. Results The initial search carried out on PubMed and the Cochrane Library for publications up to January 2018 resulted in 267 scientific articles. Six randomized controlled trials (RCTs) were met the inclusion and exclusion criteria and were selected as eligible studies. Out of six studies in this review, three studies were judged to have a low risk of bias, one study was classified as moderate risk of bias and two studies were high risk of bias. No specific adverse effect related to CPP-ACP usage was observed.  Conclusions Based on the literature, there is a tendency towards the benefits of CPP-ACP usage in addition to fluoride toothpaste and/or mouth rinse compared to fluoride toothpaste and/or mouth rinse alone on regression of early carious lesions. However, further well-designed long term clinical trials are required to establish this therapeutic strategy in the main stream clinical practice. en_US
dc.format.extent 48 en_US
dc.language.iso eng en_US
dc.publisher Malmö universitet/Odontologiska fakulteten sv-SE
dc.title Effectiveness of Casein Phosphopeptide- Amorphous Calcium Phosphate (CPP-ACP) in Remineralization of Early Carious Lesions. A systematic review en_US
dc.type H2 en_US
dc.setspec.uppsok Medicine en_US
dc.contributor.examiner Ridell, Karin
dc.contributor.supervisor Ericson, Dan
dc.contributor.supervisor Petersson, Gunnel
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